HOME > 研究 > 周産期
研究室の紹介

代表: 宮越 敬 専任講師(Kei Miyakoshi, MD,PhD)

(メンバー:松本直(専任講師)、落合大吾(助教)、春日義史(大学院生)、
   池ノ上学(大学院生)、福武麻里絵(大学院生)、大谷利光(助教)、秋葉洋平(助教))

 

1) 周産期異常に関与する遺伝要因の検討

疾患の発症には遺伝要因と環境要因が関わっており、多くは両者が複雑に関与する多因子疾患です。例えば、高血圧や糖尿病は多因子疾患の代表例であり、これまで我が国においても日本人における遺伝要因の解明が試みられてきました。一方、早産、妊娠高血圧症候群および妊娠糖尿病などの周産期異常も多因子疾患と推測されますが、日本人妊婦における遺伝要因に関する知見が少ないのが現状です。そこで現在、多施設共同で周産期異常のゲノム疫学、特に一塩基多型に関する研究を行っております。

2) 糖代謝異常合併妊娠の周産期事象に関する検討

糖代謝異常妊娠、特に妊娠糖尿病におけるインスリンを中心とした内分泌動態に関する臨床研究を進めております。また、2010年の妊娠糖尿病の診断基準改定に伴い、新基準妊娠糖尿病例の糖代謝異常、産後糖代謝異常の発症予知のための適切な指標の確立に関する研究を行っております。

 

3)合併症妊娠および周産期異常に関する臨床データの解析

当院で管理を行った合併症妊娠例について臨床データを解析しております。また、広汎性子宮頸部摘出術後妊娠の周産期予後など単一施設のみでは十分な症例数を得られない場合には、他施設とも協力して臨床データの集積・解析を行い、適切な周産期管理法の構築を目指しております。

 

■■ References ■■

Ochiai D, Miyakoshi K, Miwa T, et al. Prenatal diagnosis of thrombosed dural sinus malformation with periorbital hemangioma: a case report. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2015.

Itoh A, Saisho Y, Miyakoshi K, et al. Time-dependent changes in insulin requirement for maternal glycemic control during antenatal corticosteroid therapy in women with gestational diabetes: a retrospective study. Endocr J. 2015.

Kasuga Y, Nishio H, Miyakoshi K, et al. Pregnancy Outcomes After Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer: A 13-Year Experience in a Single Tertiary-Care Center. Int J Gynecol Cancer. 2015.

春日義史, 宮越敬 他. 総排泄腔違残症の出生前超音波像. 超音波医学. 2015;42(2):183-184.

Matsumoto T, Miyakoshi K, et al. Intracranial sonographic features demonstrating in utero development of hemorrhagic brain damage leading to schizencephaly associated COL4A1 mutation. J Med Ultrasonics. 2015;42:445-446.

Ikenoue S, Miyakoshi K, Saisho Y, et al. Clinical impact of women with gestational diabetes mellitus by the new consensus criteria: two year experience in a single institution in Japan. Endocr J. , 2014;61:353-358.

Kadohira I, Miyakoshi K, Shimojima N, et al. Fetal Stomach Paracentesis in Combined Duodenal and Esophageal Atresia. J Med Ultrasonics. 2014 Jan 14. [Epub ahead of print]

Ochiai D, Miyakoshi K, Yakubo K, et al. Familial blue rubber bleb nevus syndrome in pregnancy with spinal epidural involvement. Case Rep Obstet Gynecol. 2013;2013:141506.

Matsumoto T, Miyakoshi K, Saisho Y, et al. Antenatal management of recurrent fetal goitrous hyperthyroidism associated with fetal cardiac failure in a pregnant woman with persistent high levels of thyroid-stimulating hormone receptor antibody after ablative therapy. Endocr J. 2013;60:1281-1287.

Kim SH, Miyakoshi K, Kadohira I, Tanaka M, Minegishi K, Matsumoto T, et al. Comparison of the right and left ventricular performance during the fetal development using velocity vector imaging. Early Hum Dev. 2013 May 23.

Kasuga Y, Miyakoshi K, Ikenoue S, Kadohira I, Matsumoto T, Minegishi K, et al. Complete chorion-amnion separation presenting as a stuck fetus. Acta Obstet Gynecol Scand. 2013 May 6.

Saisho Y, Miyakoshi K, Ikenoue S, Kasuga Y, Matsumoto M, Minegishi K, et al. Marked decline in beta cell function during pregnancy leads to the development of glucose intolerance in Japanese women. Endocrine J. 2012 Dec 27. [Epub ahead of print]

Kadohira I, Miyakoshi K, Yoshimura Y. Prenatal Images of the Aortopulmonary Window With an Interrupted Aortic Arch. Pediatr Cardiol. 2012 Dec 18. [Epub ahead of print]

Miyakoshi K, Tanaka M, Morisaki H, Kim SH, Hosokawa Y, Matsumoto T, et al. Perinatal outcomes: Intravenous patient-controlled fentanyl versus no analgesia in labor. J Obstet Gynaecol Res. 2012 Nov 20. [Epub ahead of print]

Takayuki Higuchi, Mamoru Tanaka, Keiko Kuroda, Akira Yabuno, Seon Hye Kim, Satoshi Asai, Sokichi Iwata and Kei Miyakoshi: Abnormal first-trimester fetal nuchal translucency and amniotic band syndrome. J Med Ultrasound 39:177-180, 2012

Matsumoto T, Miyakoshi K, Yoshimura Y: Prenatal Images of the Truncus Arteriosus With an Interrupted Aortic Arch. Pediatr Cardiol. 2012 Aug 5. [Epub ahead of print]

Kim S-H, Tanaka M, Umezu M, Oda H, Asai S, Higuchi M, Kadohira I, Minegishi K, Miyakoshi K and Yoshimura Y: Congenitally corrected transposition of the great arteries. J Med Ultrasound 39:25-27, 2012

Saisho Y, Miyakoshi K, Tanaka M, Matsumoto T, Minegishi K, Yoshimura Y, et al. Antepartum oral disposition index as a predictor of glucose intolerance postpartum. Diabetes Care . 2012 ;35(4):e32.

6. Hosokawa Y, Morisaki H, Nakatsuka I, Hashiguchi S, Miyakoshi K, Tanaka M, et al. Retrospective evaluation of intravenous fentanyl patient-controlled analgesia during labor. J Anesth. 2012 ;26:219-24.

Matsumoto T, Miyakoshi K, Minegishi K, Tanaka M, Yoshimura Y. Fetal growth and gestational hypertension in women classified as gestational diabetes mellitus defined by the new consensus criteria only. Acta Obstet Gynecol Scand. 2012;91:272-3.

Final diagnosis in patients with congenital cystic lung disease detected by fetal ultrasonography. Kuratsuji G, Hokuto I, Higuchi M, Koinuma G, Morikawa Y, Hoshino K, Tanaka M, Miyakoshi K, Ikeda K. Pediatr Int. 2011 Feb;53(1):131-2.

Tanaka M, Miyakoshi K, Yamada M, Kadohira I, Minegishi K, Yoshimura Y. Functional foods for the fetus? Acta Obstet Gynecol Scand. 2011;90:1172-3.

Pancreatic {beta}-Cell Function in Women With Gestational Diabetes Mellitus Defined by New Consensus Criteria. Miyakoshi K, Saisho Y, Tanaka M, Shimada A, Itoh H, Yoshimura Y. Diabetes Care. 2011 Jan;34(1):e8.

Saisho Y, Miyakoshi K, Tanaka M, Shimada A, Ikenoue S, Kadohira I, Yoshimura Y, Itoh H. Beta cell dysfunction and its clinical significance in gestational diabetes. Endocr J. 2010;30:973-80.

Miyakoshi K, Tanaka M, Saisho Y, Shimada A, Minegishi K, Kim SH, Asai S, Itoh H, Yoshimura Y. Pancreatic beta-cell function and fetal growth in gestational impaired glucose tolerance. Acta Obstet Gynecol Scand. 89, 769-775, 2010

Asai S, Tanaka M, Miyakoshi H, Kim SH, Minegishi K, Matsuzaki Y, Kosaki K, Ogata H and Yoshimura Y. A case of Tessier number 7 cleft with severe micrognathia: prenatal sonographic and three-dimensional helical computed tomographic images. Prenatal Diagn. 30, 159-161, 2010

Miyakoshi K, Matsuoka M, Yasutomi D, Tanaka M, Yakubo K, Fukuiya T and Yoshimura Y. Moyamoya-disease-related ischemic stroke in the postpartum period. J Obstet Gynaecol Res. 35, 974-947, 2009

Matsumoto T, Minegishi K, Ishimoto H, Tanaka M, Hennebold JD, Teranishi T, Hattori Y, Furuya M, Higuchi T, Asai S, Kim SH, Miyakoshi K and Yoshimura Y; Expression of ovary-specific acidic protein in steroidogenic tissues: a possible role in steroidogenesis. Endocrinology 150, 3353-3359, 2009

Asai S, Ishimoto H, Kim SH, Higuchi T, Minegishi K, Tanaka M, Hoshino K, Morikawa Y and Yoshimura Y; Prenatal Diagnosis of Retroperitoneal Teratoma: A Case Report and Review of the Literature. Fetal Diagn Ther 25, 76-78, 2009

Asai S, Asada H, Furuya M, Ishimoto H, Tanaka M and Yoshimura Y; Pseudoaneurysm of the uterine artery after laparoscopic myomectomy. Fertil Steril 91, 929 e921-923, 2009

Miyakoshi K, Tanaka M, Matsumoto T, Hattori Y, Minegishi K, Ishimoto H, Yoshimura Y; Occipital scalp hemangioma: prenatal sonographic and magnetic resonance images. J Obstet Gynaecol Res 34, 666-669, 2008

Ishimoto H, Minegishi K, Higuchi T, Furuya M, Asai S, Kim SH, Tanaka M, Yoshimura Y and Jaffe RB; The Periphery of the Human Fetal Adrenal Gland Is a Site of Angiogenesis: Zonal Differential Expression and Regulation of Angiogenic Factors. J Clin Endocrinol Metab 93, 2402-2408, 2008

Furuya M, Tanaka M, Teranishi T, Matsumoto K, Hosoi Y, Saeki K, Ishimoto H, Minegishi K, Iritani A and Yoshimura Y; H1foo is Indispensable for Meiotic Maturation of the Mouse Oocyte. J Reprod Dev 53, 895-902, 2007

Ishimoto H, Muench MO, Higuchi T, Minegishi K, Tanaka M, Yoshimura Y and Jaffe RB; Midkine, a heparin-binding growth factor, selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland. J Clin Endocrinol Metab 91, 4050-4056, 2006

Ishimoto H, Ginzinger DG, Matsumoto T, Hattori Y, Furuya M, Minegishi K, Tanaka M, Yoshimura Y and Jaffe RB; Differential zonal expression and adrenocorticotropin regulation of secreted protein acidic and rich in cysteine (SPARC), a matricellular protein, in the midgestation human fetal adrenal gland: implications for adrenal development. J Clin Endocrinol Metab 91, 3208-3214, 2006

Ishimoto H, Ginzinger DG and Jaffe RB; Adrenocorticotropin preferentially up-regulates angiopoietin 2 in the human fetal adrenal gland: implications for coordinated adrenal organ growth and angiogenesis. J Clin Endocrinol Metab 91, 1909-1915, 2006

Hattori Y, Tanaka M, Matsumoto T, Uehara K, Ueno K, Miwegishi K, Ishimoto H, Miyakoshi K and Yoshimura Y; Prenatal diagnosis of hemifacial microsomia by magnetic resonance imaging. J Perinat Med 33, 69-71, 2005

Tanigaki S, Miyakoshi K, Tanaka M, Hattori Y, Matsumoto T, Ueno K, Uehara K, Nishimura O, Minegishi K, Ishimoto H, Shinmoto H, Ikeda K and Yoshimura Y; Pulmonary hypoplasia: prediction with use of ratio of MR imaging-measured fetal lung volume to US-estimated fetal body weight. Radiology 232, 767-772, 2004

Teranishi T, Tanaka M, Kimoto S, Ono Y, Miyakoshi K, Kono T and Yoshimura Y; Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer. Dev Biol 266, 76-86, 2004